Cytiva (formerly part of GE Healthcare Life Sciences) - Cytiva AxiChrom 300/300 Chromotography Column

• Protein purification in biopharmaceutical production.
• Separation of biomolecules in research and development laboratories.
• Desalting and buffer exchange of biological samples.
• Capture and polishing steps in downstream processing.
• Vaccine and plasma fractionation processes.

Column diameter

Typically 300 mm for this model.

Column length

Typically 300 mm for this model, indicating a bed height range.

Construction materials

Commonly medical-grade plastics (e.g., acrylic, polypropylene) and stainless steel for wetted parts, suitable for GMP environments.

Operating pressure

Units of this type typically operate within a specific pressure range, crucial for efficient flow rates and column packing.

Temperature range

Designed to operate within standard laboratory and bioprocessing temperatures, typically 4-40°C.

Flow rate

Throughput is dependent on column dimensions and media, but units of this size are suitable for pilot to small-scale production.

Certifications

Equipment from Cytiva is typically manufactured to meet relevant industry standards such as cGMP, FDA, and EMEA guidelines.

• What is the typical bed volume for a Cytiva AxiChrom 300/300?

  For a 300 mm diameter and 300 mm length, the nominal bed volume would be approximately 21 litres. The exact volume depends on the packed bed height.

• Is this column suitable for GMP manufacturing?

• What type of chromatography media can be used with this column?

• What maintenance is typically required for a used chromatography column?

• Does this column come with packing accessories?

Chromatography columns and accessories hold strong reputations within analytical laboratories for reliability and consistent performance. Buyers typically value used equipment that maintains original specifications and comes with documentation of maintenance history. Industry sentiment favours purchasing from reputable sources where column condition, packing integrity, and compatibility with existing systems are verified. Common strengths include durability of quality columns across multiple applications and cost savings versus new purchases. When buying used, inspecting for damage, confirming proper storage conditions, and verifying suitability for intended analytical methods remain critical considerations for laboratory operations.

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