Pall Allegro 1/2" Single Use TFF System

• Concentration and purification of proteins, vaccines, and antibodies in biopharmaceutical manufacturing.
• Diafiltration for buffer exchange and removal of small molecules from process streams.
• Clarification of cell cultures and fermentation broths in upstream bioprocessing.
• Pilot-scale and small-batch production where single-use technology minimises cross-contamination risk.

Typical membrane area

Units of this class commonly support membrane areas ranging from 0.05 m² to 0.5 m².

Flow path diameter

This specific unit features a 1/2" single-use flow path, suitable for various bioprocess volumes.

Power supply

Typically requires a standard laboratory power supply, often 230V, 50Hz for UK operation.

System footprint

For this class of benchtop system, the footprint is generally compact, suitable for laboratory or cleanroom environments.

Operating pressure range

Commonly operates within a pressure range suitable for ultrafiltration and diafiltration processes.

Materials in contact with fluid

Single-use components are typically constructed from validated biopharmaceutical-grade plastics.

Control interface

Often features an integrated control system for pump speed, pressure, and temperature monitoring.

• What is Tangential Flow Filtration (TFF)?

  TFF is a filtration method where the feed stream flows tangentially across the membrane surface, reducing membrane fouling and allowing for continuous processing.

• Why use a single-use TFF system?

• What types of membranes are compatible with this system?

• Is this system suitable for GMP environments?

• What maintenance is required for a used single-use TFF system?

Single-use bioprocess systems are valued for their flexibility, reduced contamination risk, and faster changeover between batches. Buyers appreciate the lower cleaning and validation requirements compared to reusable equipment. When purchasing used units, inspect for integrity of single-use components, verify sterility assurance levels, and confirm compatibility with existing infrastructure. Industry sentiment highlights their suitability for contract manufacturers and smaller facilities. Key considerations include supplier support availability and documentation of previous usage history to ensure reliability.

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