Spectrum Labs Krosflo 11 Automatic Backpressure Valve

• Controlling transmembrane pressure in tangential flow filtration (TFF) systems for laboratory research.
• Regulating flow and pressure in small-scale biopharmaceutical processing applications.
• Maintaining consistent backpressure for precise separation and concentration of biomolecules.
• Use in R&D settings for process development and optimisation of filtration protocols.

Typical capacity

Designed for laboratory-scale TFF systems, typically handling volumes from a few millilitres to several litres.

Pressure range

Commonly operates within a range suitable for microfiltration and ultrafiltration processes, typically up to 3-5 bar.

Control mechanism

As an automatic backpressure valve, it typically provides automated pressure regulation, often integrated with a TFF system's control unit.

Materials of construction

Wetted parts are commonly made from biocompatible materials such as stainless steel or engineering plastics suitable for laboratory use.

Connectivity

Features standard laboratory fluid connections, such as Luer lock or barbed fittings, compatible with typical TFF tubing.

Power supply

If requiring external power, units of this type typically operate on standard laboratory voltages (e.g., 230V, 50Hz in the UK) or are powered directly by the associated TFF system.

• What is the primary function of an automatic backpressure valve in a TFF system?

  Its primary function is to precisely control the transmembrane pressure (TMP) across the filtration membrane, which is crucial for efficient and consistent separation in tangential flow filtration.

• Is this valve suitable for pilot-scale or production-scale operations?

• What maintenance is typically required for this type of valve?

• Can this valve be integrated with any TFF system?

• What are the benefits of an automatic backpressure valve over a manual one?

Backpressure valves and flow control equipment earn consistent regard across laboratory, biotech, and pharmaceutical settings for reliable performance in precise fluid management. Buyers typically value models offering accurate pressure regulation and stable flow rates over extended operational periods. When purchasing used units, inspecting seals, calibration accuracy, and compatibility with specific fluid types remains important. Industry practitioners generally appreciate their durability and low maintenance demands. Corrosion-resistant materials and adjustable pressure settings are frequently cited strengths, particularly for demanding applications requiring consistent performance across varied operating conditions.

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