Waters ACQUITY UPLC System

• Pharmaceutical research and development for drug discovery and quality control.
• Biopharmaceutical analysis, including protein and peptide characterisation.
• Environmental monitoring for contaminant detection in water and soil samples.
• Food and beverage analysis to ensure product quality and safety.
• Clinical diagnostics for biomarker analysis and therapeutic drug monitoring.

Typical pressure range

Units of this type commonly operate at pressures up to 15,000 psi (1034 bar) for high-resolution separations.

Flow rate range

Typically, flow rates range from 0.01 to 2.0 mL/min, suitable for various column dimensions.

Detector options

Commonly, these systems can be configured with UV/Vis, PDA, fluorescence, or mass spectrometry detectors.

Column temperature control

Units typically offer precise temperature control from 5 °C above ambient to 90 °C.

Sample capacity

Autosamplers for this class of equipment typically accommodate multiple 96-well plates or up to 120 standard vials.

Power supply

Commonly requires a standard laboratory power supply, typically 230V, 50Hz in the UK.

Footprint

The modular design of UPLC systems means the footprint can vary, but individual modules are typically designed for benchtop placement.

• What is the primary advantage of UPLC over traditional HPLC?

  UPLC systems, like the Waters ACQUITY, utilise smaller particle columns and higher pressures, resulting in significantly faster separations, improved resolution, and increased sensitivity compared to conventional HPLC.

• Is this system suitable for method transfer from existing HPLC methods?

• What kind of maintenance does a used UPLC system typically require?

• What software is typically used to operate a Waters ACQUITY UPLC system?

• Can this system be integrated with other laboratory instruments?

Chromatography systems command strong respect within analytical and pharmaceutical sectors. Buyers typically prioritise equipment with verified maintenance records and clear calibration history, as these directly affect analytical accuracy. Used units from established manufacturers remain highly valued for their reliability. Key strengths include reproducible results, robust construction, and established spare parts availability. Industry sentiment reflects confidence in these systems when sourced from reputable suppliers with transparent service documentation.

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