PAL (Cytiva) C145824 Retentate Filtration

• Concentration of biological samples such as proteins, viruses, and nucleic acids.
• Clarification of cell cultures and fermentation broths.
• Buffer exchange and diafiltration in downstream bioprocessing.
• Purification of vaccines and therapeutic proteins.
• Laboratory-scale process development and optimisation.

Typical capacity

For this class of laboratory filtration system, typical processing volumes can range from several millilitres to a few litres, depending on the specific membrane area and configuration.

Power supply

Units of this type commonly operate on standard laboratory single-phase electrical supplies, typically 230V, 50Hz in the UK.

Membrane type

Retentate filtration systems commonly utilise tangential flow filtration (TFF) membranes, available in various pore sizes and materials (e.g., polysulfone, regenerated cellulose) to suit different applications.

Operating pressure

Typical operating pressures for laboratory-scale TFF systems are generally in the range of 0.5 to 5 bar, depending on the membrane and fluid characteristics.

Footprint

For a laboratory filtration system, the footprint is typically compact, designed for benchtop use within a laboratory environment.

Materials of construction

Wetted parts are commonly constructed from biocompatible materials such as stainless steel, PTFE, and silicone, suitable for biopharmaceutical applications.

• What is retentate filtration?

  Retentate filtration, often referring to tangential flow filtration (TFF), is a process where a liquid sample is passed tangentially across a membrane surface. This allows smaller molecules and solvent to pass through (permeate) while larger molecules are retained and concentrated (retentate).

• What are the key benefits of using a TFF system for concentration?

• Is this system suitable for sterile applications?

• What maintenance is typically required for this type of equipment?

• Can different membrane types be used with this system?

Laboratory filtration systems are valued for reliability and durability, making them suitable for used purchase when sourced carefully. Buyers typically prioritise checking membrane and filter condition, as replacement costs can be significant. Industry sentiment favours systems from established manufacturers known for consistent performance. Common strengths include robust construction, compatibility with various applications, and availability of spare parts. When assessing used units, verifying maintenance history and operational specifications remains essential for ensuring continued performance in biotech and pharmaceutical environments.

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