Waters Acquity H-Class UPLC System

• Pharmaceutical analysis for drug discovery, development, and quality control.
• Chemical analysis in research and development, and process monitoring.
• Environmental testing for pollutant detection and water quality assessment.
• Food and beverage analysis for quality control and contaminant screening.
• Biotechnology applications for protein and peptide analysis.

Typical throughput

High-throughput capabilities are common for this class, allowing for rapid analysis of multiple samples.

Power supply

Units typically require standard laboratory power, commonly 230V, 50Hz in the UK, with specific amperage requirements varying by configuration.

Footprint

A modular design is typical, requiring bench space for the main modules (pump, autosampler, detector) and often a solvent manager.

Operating pressure

UHPLC systems like the Acquity H-Class are designed to operate at significantly higher pressures than traditional HPLC, typically up to 15,000 psi (1000 bar) or more.

Detector options

Commonly integrated with various detectors such as UV/Vis, PDA, fluorescence, or mass spectrometry for comprehensive analysis.

Software integration

Typically controlled by proprietary software, offering data acquisition, processing, and system diagnostics.

• What is the primary advantage of a UHPLC system like the Waters Acquity H-Class over traditional HPLC?

  UHPLC systems offer significantly faster analysis times, improved resolution, and increased sensitivity due to smaller particle columns and higher operating pressures compared to traditional HPLC.

• Is this system suitable for regulated environments?

• What kind of maintenance does a UHPLC system typically require?

• Can this system be integrated with other analytical instruments?

• What types of samples can be analysed with this equipment?

Chromatography systems command strong respect within analytical and pharmaceutical sectors. Buyers typically prioritise equipment with verified maintenance records and clear calibration history, as these directly affect analytical accuracy. Used units from established manufacturers remain highly valued for their reliability. Key strengths include reproducible results, robust construction, and established spare parts availability. Industry sentiment reflects confidence in these systems when sourced from reputable suppliers with transparent service documentation.

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