Millipore Pro Flux M30 Tangential Flow Filtration System

• Concentration and diafiltration of proteins, vaccines, and antibodies in biopharmaceutical production.
• Clarification and purification of cell cultures and fermentation broths.
• Separation of macromolecules from smaller molecules in laboratory and pilot-scale settings.
• Buffer exchange and desalting of sensitive biological products.
• Virus removal and purification in bioprocessing workflows.

Typical capacity

For this class of equipment, units typically handle batch volumes ranging from 10 litres up to several hundred litres, depending on membrane area and pump configuration.

Power supply

Commonly found on units of this type, a 3-phase electrical supply (e.g., 400V, 50Hz) is typically required, with specific amperage varying by pump size.

Membrane compatibility

ProFlux systems are typically designed to accommodate a range of Millipore Pellicon cassettes, offering various pore sizes and membrane materials (e.g., regenerated cellulose, polyethersulfone).

Flow rate

Typical recirculation flow rates for the M30 model can range from 1 to 30 litres per minute, depending on the pump and cassette configuration.

Control system

Units commonly feature integrated control systems for automated operation, including pressure, flow, and temperature monitoring.

Materials of construction

Wetted parts are typically constructed from 316L stainless steel and USP Class VI compliant polymers, suitable for pharmaceutical applications.

• What is Tangential Flow Filtration (TFF)?

  TFF is a filtration method where the feed stream flows tangentially across the membrane surface, rather than perpendicularly. This minimises membrane fouling and allows for continuous processing.

• What is the difference between ultrafiltration and diafiltration?

• Are membranes included with a used system?

• What kind of maintenance does a TFF system require?

• Can this system be used for sterile applications?

Separators and extraction systems are valued for their reliability in sample preparation workflows across laboratory and pharmaceutical settings. Buyers typically seek equipment with robust construction and minimal downtime history. Key considerations when purchasing used units include chamber integrity, seal condition, and calibration documentation. Industry sentiment favours models offering consistent reproducibility and easy maintenance. Established brands generally command confidence due to parts availability and technical support, though thorough inspection and performance testing remain essential before purchase.

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