What are the primary benefits of a cryogen-free controlled rate freezer?

Cryogen-free systems eliminate the need for liquid nitrogen or alcohol, reducing contamination risks, fire hazards, and operational costs associated with cryogen handling and storage. They are suitable for sterile environments.

How does controlled rate freezing improve sample viability?

Controlled rate freezing minimises intracellular ice crystal formation and osmotic shock, which are major causes of cell damage during cryopreservation. This leads to higher cell viability and recovery rates upon thawing.

Is this unit suitable for use in a cleanroom?

Yes, the cryogen-free design of the Grant CRF-1 makes it particularly well-suited for use in cleanrooms and barrier facilities, as it eliminates potential contamination from liquid nitrogen or alcohol.

What types of samples can typically be processed by this equipment?

This type of controlled rate freezer is designed for a wide range of biological samples, including embryos, stem cells, mammalian cells, spermatozoa, antibodies, tissue sections, and small organs.

What maintenance is typically required for a cryogen-free freezer?

Maintenance commonly involves routine cleaning, checking refrigeration system components, and ensuring calibration of temperature sensors. Regular servicing by a qualified technician is recommended to ensure optimal performance.

Used Grant CRF-1 Controlled Rate Freezer - Laboratory Freezers, photo 1

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Used Grant CRF-1 Controlled Rate Freezer - Laboratory Freezers, photo 7

Used Grant CRF-1 Controlled Rate Freezer - Laboratory Freezers

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Grant CRF-1 Controlled Rate Freezer

Name: Grant CRF-1 Controlled Rate Freezer
Brand: Grant CRF-1 Controlled Rate Freezer
SKU: 51136
Price: 4750 GBP
Availability: InStock

Price: £ 4,750

This listing is for a Grant Controlled Rate Freezer - CRF-1.

The unit is in full working condition and is ready for immediate release.

Product Overview:

The CRF-1 Liquid Nitrogen-Free Controlled Rate Freezer is designed for precision-controlled freezing and cryopreservation of biological samples, such as embryos, stem cells, mammalian cells, spermatozoa, antibodies, tissue sections, and rodent organs.

Unlike conventional liquid nitrogen-based freezers, the CRF-1 is liquid nitrogen and cryogen-free, eliminating contamination risks and making it suitable for use in cleanrooms and barrier facilities.

It offers superior performance in terms of cell viability post-freezing and poses no fire hazard, unlike alcohol-based systems.

The CRF-1 allows for highly accurate, reproducible, and controlled freezing rates, crucial for the cryopreservation of biological samples, ensuring optimal recovery upon thawing.

Key Features:

Cryogen-Free Design: The CRF-1 is free from liquid nitrogen and alcohol, offering a safer, cleaner alternative to traditional freezing methods.
No contamination risk, making it ideal for use in sterile environments.
Precise Cooling Control: The cooling rate is accurately controlled, especially for the critical nucleation/seeding phase, which ensures consistent and optimal recovery of cells.
Wide Temperature Range: Capable of cooling down to -100°C with straws, offering a broad application range for biological cryopreservation.
Simple Operation: The CRF-1 operates with or without a PC, and it can log data via PC software.
Cooling profiles are displayed directly and can be customized.
High Versatility: Compatible with cryovials, straws, bags, microplates, and Matrix-96-well block plates, allowing for research across multiple areas like stem cell research, transgenic embryos, mammalian cells, and more.
Low Operational Costs: The CRF-1 runs at approximately 1% of the cost of liquid nitrogen-based freezing systems.
Safety Features: Includes an optional Un-interruptible Power Supply (UPS) for complete cycle continuation in case of power failure.
Compact & Quiet: Fits neatly on a bench-top and operates quietly, making it suitable for laboratory settings.

Main Applications:

Transgenic embryos research
Stem cell research
Clinical and research samples like lymphocytes and tissue cell lines
Mammalian cell preservation (e.g., cardiomyocytes, adipose, liver, muscle)
Cord blood-derived stem cells
Adherent cells and stem cells in microplates
Cell suspensions in numbered/barcoded arrays
Robotic integration for high-throughput applications
Veterinarian IVF applications

Technical Specifications:

Dimensions (w x d x h): 264 x 367 x 445 mm

Weight: 9.8 kg

Max Plate Temperature: 30°C

Min Plate Temperature: -80°C (standard) or -100°C (dependent on model)

Temperature Accuracy: ±0.5°C

Temperature Stability: ±0.1°C

Temperature Uniformity: ±1.0°C

Max Cooling Rate: 10°C/min

Max Temperature Stabilization Time: 5 minutes

Key Benefits:

Accurate and Reproducible Cooling Rates: Ensures controlled freezing rates and precise sample temperature management.
Customizable Cooling Profiles: Choose from linear and non-linear profiles, or create your own tailored profile.
No Cryogen or Liquid Nitrogen: Ideal for reducing contamination risk and the cost of liquid nitrogen.
Low Running Costs: Estimated to cost only 1% of traditional liquid nitrogen-controlled freezing methods.
End-of-Cycle Cooling Stability: Maintains a steady -100°C temperature for straw applications until the freezer is switched off.
CE Marked: For laboratory use in compliance with safety and quality standards.

The unit is in full working condition and is ready for immediate release.

Cambridgeshire, United Kingdom

5,773 km away

Model Number

CRF-1 Controlled Rate Freezer

Stock Number

51136

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Cryopreservation of biological samples such as embryos, stem cells, and mammalian cells.
Controlled freezing of spermatozoa and antibodies for long-term storage.
Preparation and preservation of tissue sections and rodent organs for research.
Use in cleanroom and barrier facilities where liquid nitrogen or alcohol contamination is a concern.

Cooling Method: Cryogen-free, typically utilising compressor-based refrigeration.
Temperature Range: Capable of reaching temperatures down to -100°C for this class of equipment.
Cooling Rate Control: Offers precise and reproducible control over freezing rates, particularly during the nucleation phase.
Sample Capacity: Varies by configuration, but typically accommodates multiple vials, straws, or cryobags.
Power Supply: Commonly operates on standard laboratory single-phase electrical supply (e.g., 230V, 50Hz in the UK).
Footprint: Benchtop or compact floor-standing unit, depending on the specific model and accessories.

Cryogen-free systems eliminate the need for liquid nitrogen or alcohol, reducing contamination risks, fire hazards, and operational costs associated with cryogen handling and storage. They are suitable for sterile environments.

Blast freezers hold strong reputations for reliable performance in food processing operations. Buyers typically prioritise units with sturdy construction and consistent temperature control, as these directly affect product quality and shelf life. When purchasing used equipment, inspecting refrigeration systems, door seals and internal surfaces for wear is essential. Industry sentiment favours models from established manufacturers known for durability. Key strengths include rapid freezing capability, energy efficiency compared to older freezing methods, and adaptability to various food types. Proper maintenance history significantly influences buyer confidence in used units.

General overview for this equipment type

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.