PAL (Cytiva) C145824 Retentate Filtration

• Concentration and purification of biomolecules in laboratory and pilot-scale settings.
• Buffer exchange for protein solutions and other biopharmaceutical products.
• Process development and optimisation for larger-scale filtration systems.
• Small batch production in pharmaceutical and biotechnology industries.
• Phase I clinical studies requiring sterile and precise separation.

Typical capacity

For this class of equipment, processing volumes typically range from several litres up to tens of litres, depending on the installed membrane area.

Power supply

Units of this type commonly require a standard single-phase electrical supply for ancillary pumps and controls, typically 230V, 50Hz in the UK.

Materials of construction

Commonly, wetted parts are constructed from 316L Stainless Steel or Ultra-High Molecular Weight Polyethylene (PE) for chemical compatibility and durability.

Membrane compatibility

This equipment typically supports a variety of TFF membrane types (e.g., ultrafiltration, microfiltration) and molecular weight cut-offs (MWCOs) to suit specific separation needs.

Footprint

For this size of unit, a compact benchtop or small mobile cart footprint is typical, suitable for laboratory or cleanroom environments.

Operating pressure

Operating pressures for retentate filtration systems commonly range from 0.5 to 5 bar, depending on the membrane and application.

• What is retentate filtration?

  Retentate filtration, often referring to Tangential Flow Filtration (TFF), is a process where a fluid is passed tangentially across a membrane, allowing smaller molecules to pass through (permeate) while larger molecules are retained and concentrated (retentate).

• What are Pall Centramate holders used for?

• Can this unit be scaled up for larger production?

• What maintenance is typically required for this equipment?

• Is this unit suitable for sterile applications?

Laboratory filtration systems are valued for reliability and durability, making them suitable for used purchase when sourced carefully. Buyers typically prioritise checking membrane and filter condition, as replacement costs can be significant. Industry sentiment favours systems from established manufacturers known for consistent performance. Common strengths include robust construction, compatibility with various applications, and availability of spare parts. When assessing used units, verifying maintenance history and operational specifications remains essential for ensuring continued performance in biotech and pharmaceutical environments.

General overview for this equipment type