Pall Allegro 1/2" Single Use TFF System

• Concentration and diafiltration of proteins, vaccines, and other biologics in pharmaceutical manufacturing.
• Clarification of cell cultures and fermentation broths in biotechnology.
• Buffer exchange and purification steps in laboratory and pilot-scale bioprocessing.
• Virus filtration and removal in the production of biopharmaceuticals.

Typical capacity

Recirculation pump capacities for this class of equipment commonly range from hundreds to over 1,000 litres per hour, suitable for various batch sizes.

Power supply

Units of this type typically operate on standard industrial single-phase or three-phase electrical supplies, commonly 230V or 400V, 50Hz in the UK.

Footprint

For systems mounted on a trolley, the footprint is generally compact, allowing for mobility within a laboratory or production environment.

Control system

Modern TFF systems often feature integrated control panels with automated monitoring and control of critical process parameters.

Materials of construction

Process-contacting parts are typically single-use plastic manifolds and membranes, while the system frame and housing are commonly stainless steel.

Membrane area

The effective membrane area for 1/2" systems is typically designed for processing volumes ranging from laboratory to pilot scale.

• What are the primary benefits of a single-use TFF system?

  Single-use TFF systems eliminate the need for cleaning validation, reduce the risk of cross-contamination, and offer enhanced flexibility and faster turnaround times between batches.

• Is this system suitable for both ultrafiltration and diafiltration?

• What kind of maintenance is typically required for a single-use TFF system?

• Are the single-use components readily available?

• Can this system be integrated into existing bioprocessing workflows?

Single-use bioprocess systems are valued for their flexibility, reduced contamination risk, and faster changeover between batches. Buyers appreciate the lower cleaning and validation requirements compared to reusable equipment. When purchasing used units, inspect for integrity of single-use components, verify sterility assurance levels, and confirm compatibility with existing infrastructure. Industry sentiment highlights their suitability for contract manufacturers and smaller facilities. Key considerations include supplier support availability and documentation of previous usage history to ensure reliability.

General overview for this equipment type