Thermo Scientific - Vanquish UHPLC System

This listing is for the Thermo Scientific Vanquish UHPLC Sytem

The unit is in full working condition and is ready for immediate use

Overview: Thermo Scientific Vanquish UHPLC Systems

1. Autosampler

Purpose: Introduces the sample into the mobile phase stream automatically.

Picks up sample from vials, plates, or tubes

Injects with high precision (often nL to µL volume range

Module

Purpose: Delivers the mobile phase (solvent) through the system at high pressure.

Binary pump: Mixes two solvents at high pressure. Ideal for fast gradients.

Quaternary pump: Mixes up to four solvents at low pressure. More flexible, but slower gradients.

Controls flow rate (e.g., 0.001–5.000 mL/min)

Enables gradient elution (changing solvent composition over time

Module (x2)

Purpose: Detects and measures analytes as they elute from the column.

Diode Array Detector (DAD/UV-Vis) – most common; detects UV-absorbing compounds

Fluorescence Detector – for fluorescent compounds

Charged Aerosol Detector (CAD) – universal detection for non-UV compounds

Refractive Index Detector – for sugars, polymers

MS (Mass Spectrometer) – advanced, highly sensitive detection

Thermo Fisher’s Vanquish platform includes several variants tailored to different analytical needs—from routine HPLC to ultra-high-throughput and low-flow LC–MS workflows:

Vanquish Flex UHPLC: Offers flexible HPLC/UHPLC method development and operates up to 1000 bar. It supports binary, quaternary, and dual pumps, plus intelligent tools like solvent monitoring and optional touchscreen interface.

Vanquish Horizon UHPLC: Built for maximum performance, offering ultra-high pressure (up to 1500 bar), ultra-low gradient delay volume, biocompatible flow paths, and exceptional retention time stability and detector sensitivity.

Vanquish Neo UHPLC: Designed for next-gen low-flow LC‑MS workflows (nano‑ to micro‑flow), delivering high‑sensitivity, high‑robustness separations.

Vanquish Analytical Purification LC: Specialized for precise fractionation—high pressure (700–1500 bar), customizable flow (up to 10 mL/min), integrated fraction collector, multimodal detection, and advanced automation.

Key Features Across the Platform

Modular Design: Choose components (pumps, samplers, detectors, thermostatting units) to configure a tailored system. Most models offer biocompatible flow paths and Viper fingertight fittings for low dead‑volume, tool‑free setup.

Temperature Control: High-performance column compartments with active/passive heating, pre‑heating, and post‑column cooling to manage frictional heating and improve reproducibility.

Detection Options: Available detectors include Diode Array (with LightPipe optics for superb sensitivity), Charged Aerosol Detector (CAD) for near‑universal detection, fluorescence, multi‑wavelength, refractive index, and mass spectrometry detection.

Software Integration: Fully compatible with Chromeleon CDS (with SII for streamlined MS integration), plus Xcalibur and TraceFinder for LC‑MS workflows.

MS Integration: Vanquish systems interface seamlessly with Thermo MS platforms—Triple Quadrupole and Orbitrap—for sensitive, accurate mass analysis.

Operational ROI: Thermo highlights reduced unplanned repairs, improved productivity, and net-zero ambitions through renewable-powered manufacturing.