Automated Synthesizers
Building a peptide or an oligonucleotide by hand is slow, error prone and hard to reproduce, which is exactly why automated synthesisers exist. These instruments run the repetitive couple, wash and deprotect cycles of solid phase synthesis under program control, producing sequences reliably batch after batch, and they sit within the wider Lab Automation, Robotics & Workstations range. Buyers weigh the synthesis chemistry supported, the number and scale of columns and the reagent handling. Listings describe the synthesis type and throughput, covering both new and used synthesisers, so you can match an instrument to your work. Contact the seller to confirm the automated synthesiser suits your chemistry and scale.
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Automated Synthesizer Types
Automated synthesisers divide by the molecules they build and by their scale. The variants suit peptides, oligonucleotides and small molecule chemistry.
Peptide synthesisers
Instruments that assemble peptides through solid phase couple and deprotect cycles. They produce sequences at research to production scale with repeatable quality.
Oligonucleotide synthesisers
Systems that build DNA and RNA sequences base by base on a solid support. They automate the phosphoramidite chemistry behind custom oligos.
Small molecule and flow synthesisers
Instruments that run programmed reaction steps for small molecule synthesis. Flow designs improve control and reproducibility over manual routes.
Multi column parallel synthesisers
Units with several columns that build multiple sequences at once. They raise throughput for libraries and parallel synthesis.
Latest Automated Synthesizers Listings
Why Choose Machinery Masters
Verified Sellers Only
Every seller is verified before a single listing goes live. Machinery Masters also reviews listings for accuracy, so buyers can commit to high value machinery with confidence.
Global Reach
Listings come from sellers across Europe, North America, and beyond. That reach widens the options past any regional dealer network, and it is often the only way to find discontinued models in good condition.
Flexible Financing Options
Qualifying listings carry financing through partner providers. Terms are shown directly on eligible product pages, spreading the cost instead of draining working capital in one hit.
Direct Seller Contact
No broker sits between the buyer and the seller. Ask about service history, arrange inspections, and negotiate directly with the person who actually knows the machine.
Applications and Uses
Automated synthesisers build molecules through repeatable programmed chemistry. These are their core uses.
Custom peptide production
Synthesising peptides for research, assay development and therapeutic work. The instrument repeats the coupling cycles to give consistent sequences.
Oligonucleotide synthesis
Producing custom DNA and RNA oligos for primers, probes and gene work. Automated cycles build accurate sequences base by base.
Compound library synthesis
Building sets of related molecules for screening through parallel synthesis. Multi column instruments raise the throughput of library work.
Small molecule route automation
Running defined reaction sequences for reproducible small molecule synthesis. Programmed control improves consistency over manual chemistry.
Benefits from Machinery Masters
The marketplace lists automated synthesisers across peptide, oligo and small molecule chemistry, each with clear detail on scale.
Peptide, oligo and small molecule instruments together
Synthesisers for every synthesis chemistry sit in one category for side by side comparison. That range lets you match the automated synthesiser to your chemistry and scale in a single search.
Refurbished synthesisers well below new cost
A serviced automated synthesiser performs reliably for a fraction of the new price. The saving can cover reagents, columns and a service plan.
Chemistry and scale checked with the seller
You confirm the supported chemistry, column count and batch scale directly before buying. That check keeps the used synthesiser aligned with the sequences you produce.
Frequently Asked Questions About Automated Synthesizers
Automated synthesisers are built around a specific chemistry, whether peptide coupling, phosphoramidite oligo synthesis or small molecule reactions. An instrument for one will not build the other without major change. Confirm the chemistry the listed unit runs and the reagents it expects. Tell the seller what you synthesise so they can confirm the synthesiser matches your chemistry.
Scale is set by the column size and the reagent delivery, while column count sets how many sequences you build at once. Research quantities need a small scale, while production or library work needs more capacity or parallel columns. Note your typical batch and sequence numbers. Give the seller those figures so they can confirm the automated synthesiser covers your scale.
Check the reagent delivery lines, valves and any pumps, since these wet parts wear and clog with synthesis reagents. Ask whether the used synthesiser has been serviced and run recently and whether it holds delivery accuracy. Blocked lines and worn valves cause failed couplings. A unit with a clear service record and confirmed function is a sound buy.
Synthesis consumes activators, protected building blocks, solvents and columns, and these add up over a campaign. Ask which reagents and column formats the synthesiser expects and whether any are included. Confirm the consumables are still available for the chemistry. Knowing the running cost lets you budget beyond the purchase price.
Reach the seller directly to ask for a live demonstration or a recorded clip of the synthesiser running a cycle. Because there is no middleman, arranging that is straightforward. Sellers on the marketplace are verified, which adds confidence to the exchange. Agree any inspection terms before you complete the purchase.