Cytiva (formerly part of GE Healthcare Life Sciences) - Cytiva AxiChrom 300/300 Chromotography Column

Applications & Use Cases

• Purification of biopharmaceuticals such as antibodies, vaccines, and recombinant proteins.
• Separation and purification in process development and manufacturing within the biotech industry.
• Use in GMP-compliant environments for critical bioprocessing steps.
• Large-scale chromatographic separations requiring high resolution and reproducibility.

Typical Specifications

Column Inner Diameter

This specific unit has a 300 mm i.d., which is suitable for pilot to production scale.

Bed Height

This unit is configured for a 300 mm bed height, commonly adjustable for this class of equipment to suit various process needs.

Operating Pressure

Typically designed for low-pressure chromatography applications, suitable for soft media.

Materials of Construction

Wetted parts commonly comply with USP Class VI and 21 CFR part 177, ensuring suitability for pharmaceutical use.

Packing Method

Features automated axial compression packing, ensuring reproducible bed density and performance.

Sanitisation

Designed for effective cleaning and sanitisation, including treatment with 1 M NaOH, crucial for GMP compliance.

Frequently Asked Questions

• What is axial compression chromatography?

  Axial compression chromatography involves applying pressure to the chromatography bed in the axial direction, which helps to maintain bed stability and improve separation efficiency, especially with soft media.

• Is this column suitable for GMP environments?

• What types of media can be used with this column?

• How does the 'swing-out' tube feature benefit operation?

• Can the bed height be adjusted?