Cytiva (formerly part of GE Healthcare Life Sciences) - Cytiva AxiChrom 300/300 Chromotography Column

• Purification of biopharmaceuticals, such as monoclonal antibodies and vaccines.
• Separation of proteins, peptides, and nucleic acids in biotechnology processes.
• Process development and scale-up for chromatographic purification steps.
• Manufacturing of active pharmaceutical ingredients (APIs) requiring high purity.
• Downstream processing in biopharmaceutical production facilities.

Typical Inner Diameter (i.d.)

This unit is specified at 300 mm; for this class, i.d. commonly ranges from laboratory scale up to large production sizes.

Typical Bed Height

This unit is specified at 300 mm; for AxiChrom columns, bed heights are typically configurable, often between 10 cm and 50 cm for larger diameters.

Operating Pressure

AxiChrom columns are designed for low-pressure chromatography applications.

Materials of Construction

Wetted parts typically comply with USP Class VI and 21 CFR part 177, suitable for GMP environments.

Sanitisation Capability

Designed for effective cleaning and sanitisation, including treatment with 1 M NaOH, to meet microbial and endotoxin removal requirements.

Packing Method

Features automated axial compression packing for reproducible bed density and performance.

GMP Compliance

Built for GMP-compatible use, with traceable parts and materials meeting relevant regulatory requirements.

• What is axial compression packing?

  Axial compression packing is an automated method used in chromatography columns to create a uniformly dense and stable chromatography bed, which is crucial for reproducible separation performance and scalability.

• Can this column be used with different chromatography media?

• What maintenance is typically required for these columns?

• Is this unit suitable for large-scale production?

• What are the power requirements for an AxiChrom column?

Chromatography columns and accessories hold strong reputations within analytical laboratories for reliability and consistent performance. Buyers typically value used equipment that maintains original specifications and comes with documentation of maintenance history. Industry sentiment favours purchasing from reputable sources where column condition, packing integrity, and compatibility with existing systems are verified. Common strengths include durability of quality columns across multiple applications and cost savings versus new purchases. When buying used, inspecting for damage, confirming proper storage conditions, and verifying suitability for intended analytical methods remain critical considerations for laboratory operations.

General overview for this equipment type