What is axial compression chromatography?

Axial compression chromatography involves applying pressure to the chromatography bed in the axial direction, which helps to maintain bed stability and improve separation efficiency, especially with soft media.

Is this column suitable for GMP environments?

Yes, AxiChrom columns are specifically designed for GMP-compatible use, with traceable materials and features supporting sanitisation and regulatory compliance.

What types of media can be used with this column?

These columns are typically designed for use with a wide range of chromatography media, particularly those used in biopharmaceutical purification, including ion exchange, affinity, and size exclusion resins.

How does the 'swing-out' tube feature benefit operation?

For larger diameter columns like this 300 mm unit, the swing-out tube design provides easier access to the bed supports, seals, and O-rings, simplifying maintenance and validation procedures.

Can the bed height be adjusted?

While this unit is configured for a 300 mm bed height, AxiChrom columns commonly offer flexibility in bed height configurations, typically ranging from 10 cm to 50 cm for this class of equipment.

used Equipment

Available

Verified seller

Cytiva (formerly part of GE Healthcare Life Sciences) - Cytiva AxiChrom 300/300 Chromotography Column

Name: Cytiva AxiChrom 300/300 Chromotography Column
Brand: Cytiva (formerly part of GE Healthcare Life Sciences)
SKU: 43844.3A
Availability: InStock

Price: Contact seller for price

This listing is for the Cytiva AxiChrom 300/300 Chromotography collumn

The unit is in full working condition and is ready for immediate use

AxiChrom is a line of low-pressure, axial compression chromatography columns designed for process development and manufacturing of biopharmaceuticals. They are built for GMP‐compatible use, scalable from lab/ pilot to full production

300 mm inner diameter (i.d.)

300 mm bed height (column length) or related bed volume configuration

Features

Axial compression packing (intelligent packing): preprogrammed / automated methods for packing, ensuring reproducible bed density / performance.

“Swing‑out” tube or movable adapters: for large diameters (≥ 300 mm), the column tube swings out to allow easier access to the bed supports, seals and O‑rings.

Sanitization / Cleaning / GMP compliance:

Parts (“wetted” and “pressure retaining”) are traceable by batch, and materials comply with USP Class VI, 21 CFR part 177, EMEA regulatory requirements.

Cleaning and sanitization are feasible, including treatment with 1 M NaOH, with effectiveness for microbial and endotoxin removal.

Flexible configurations: options for different bed heights (usually ~10‑50 cm for large diameters) and different bed support types

Cambridgeshire, United Kingdom

5,791 km away

Model Number

AxiChrom 300/300

Stock Number

43844.3A

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Purification of biopharmaceuticals such as antibodies, vaccines, and recombinant proteins.
Separation and purification in process development and manufacturing within the biotech industry.
Use in GMP-compliant environments for critical bioprocessing steps.
Large-scale chromatographic separations requiring high resolution and reproducibility.

Typical Specifications

Column Inner Diameter: This specific unit has a 300 mm i.d., which is suitable for pilot to production scale.
Bed Height: This unit is configured for a 300 mm bed height, commonly adjustable for this class of equipment to suit various process needs.
Operating Pressure: Typically designed for low-pressure chromatography applications, suitable for soft media.
Materials of Construction: Wetted parts commonly comply with USP Class VI and 21 CFR part 177, ensuring suitability for pharmaceutical use.
Packing Method: Features automated axial compression packing, ensuring reproducible bed density and performance.
Sanitisation: Designed for effective cleaning and sanitisation, including treatment with 1 M NaOH, crucial for GMP compliance.

Frequently Asked Questions

Axial compression chromatography involves applying pressure to the chromatography bed in the axial direction, which helps to maintain bed stability and improve separation efficiency, especially with soft media.

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.