What is Tangential Flow Filtration (TFF)?

TFF is a filtration method where the feed stream flows tangentially across the surface of a membrane, rather than perpendicularly through it. This minimises membrane fouling and allows for continuous processing.

What are the primary benefits of using a TFF system like the Pro Flux M30?

Key benefits include efficient concentration and diafiltration, scalability, reduced membrane fouling compared to dead-end filtration, and suitability for processing shear-sensitive biomolecules.

Can this system be used for both research and production?

Units of this model are typically designed for laboratory and pilot-scale operations, with inherent scalability to larger production environments, making them versatile for various stages of development.

What kind of maintenance does a TFF system require?

Routine maintenance typically involves cleaning-in-place (CIP) and storage procedures for membranes, periodic calibration of sensors, and inspection of pumps and tubing for wear.

Is this system suitable for sterile applications?

Given its stainless steel construction and design, this class of equipment is generally suitable for aseptic operation and can be integrated into sterile processing workflows, often requiring sterilisation-in-place (SIP) capabilities.

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Millipore - Pro Flux M30 Tangential Flow Filtration System

Name: Pro Flux M30 Tangential Flow Filtration System
Brand: Millipore
SKU: 26611
Availability: InStock

Price: Contact seller for price

This listing is for a Millipore Pro Flux M30 Tangential Flow Filtration (TFF) System.

The unit is in full working condition and is ready for immediate release.

The Millipore Pro Flux M30 is a high-performance tangential flow filtration (TFF) system designed for demanding applications in the biotechnology, pharmaceutical, and molecular diagnostics sectors. Optimized for crossflow filtration, the M30 provides reliable separation, concentration, and clarification of biomolecules and cell suspensions in both R&D and process-scale environments.

With its robust stainless steel construction, precise transmembrane pressure (TMP) control, and compatibility with a wide range of membrane chemistries, the M30 delivers consistent performance across various filtration tasks—from protein concentration and virus clarification to cell culture harvest and synthetic biology sample prep.

Key Features

Stainless Steel Construction – Durable, sanitary design for aseptic operation and long-term reliability.

Optimized TMP Control – Ensures maximum membrane efficiency and longevity through precise pressure regulation.

Broad Membrane Compatibility – Supports a variety of membrane types and molecular weight cut-offs for flexible application use.

Process Versatility – Suitable for concentration, diafiltration, and clarification steps in upstream and downstream workflows.

Compact & Scalable – Ideal for laboratory-scale operations with scalability to pilot and production environments.

User-Friendly Interface – Intuitive controls and gauges for straightforward operation and monitoring.

Technical Specifications

Model: Pro Flux M30

Flow Configuration: Tangential Flow / Crossflow

Material of Construction: 316L Stainless Steel

Pump Type: Peristaltic or Diaphragm (depending on setup)

Pressure Control: Manual and/or automated transmembrane pressure regulation

Operating Pressure Range: Typically up to 4 bar (60 psi)

Filter Compatibility: Millipore Pellicon, Ultracel, Durapore, and other cassettes

Tubing & Fittings: Sanitary-grade with tri-clamp or Luer lock connections

Footprint: Compact benchtop design

Manufacturer: Millipore (now part of Merck Millipore)

Applications

Biopharmaceutical Processing – Protein concentration, buffer exchange, and virus removal.

Cell Culture Harvesting – Clarification of cell suspensions post-fermentation or bioreactor.

Synthetic Biology – Preparation of cell-free extracts, nucleic acid concentration, and purification.

Gene Editing & Molecular Cloning – Sample concentration and buffer exchange before downstream analysis.

Diagnostics Manufacturing – Filtration of assay components and reagent prep for diagnostic kits.

Fluorescence & Imaging Sample Prep – Ensures clean, debris-free samples for accurate analysis.

Benefits

Reliable Performance – Delivers consistent and reproducible results for critical bioprocess steps.

Process Flexibility – Adaptable to a wide range of biomolecule sizes and sample types.

Aseptic Operation – Designed for cleanroom and GMP environments.

Low Hold-Up Volume – Minimizes product loss during filtration.

Trusted Brand – Developed by Millipore, a global leader in membrane filtration technologies.

Cambridgeshire, United Kingdom

5,791 km away

Model Number

Pro Flux M30

Stock Number

26611

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Concentration and diafiltration of proteins, antibodies, and vaccines.
Clarification of cell cultures and fermentation broths.
Virus filtration and removal in biopharmaceutical manufacturing.
Sample preparation for analytical and purification steps.
Buffer exchange and desalting of biomolecules.

Typical Specifications

Typical capacity: For this class of system, it typically handles volumes from 1 to 30 litres, depending on membrane area and application.
Power supply: Commonly requires a standard single-phase electrical supply, typically 230V, 50Hz for UK operation.
Membrane compatibility: Units of this type are compatible with a wide range of flat sheet or hollow fibre membranes from various manufacturers, offering flexibility in molecular weight cut-offs and chemistries.
Construction material: Typically features wetted parts constructed from 316L stainless steel and sanitary elastomers, suitable for pharmaceutical applications.
Control system: Commonly includes integrated controls for transmembrane pressure (TMP), flow rate, and temperature, often with a user-friendly interface.
Footprint: For a laboratory-scale unit, the footprint is typically compact, designed for benchtop or mobile cart placement.

Frequently Asked Questions

TFF is a filtration method where the feed stream flows tangentially across the surface of a membrane, rather than perpendicularly through it. This minimises membrane fouling and allows for continuous processing.

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.