What are the primary benefits of a single-use TFF system?

Single-use TFF systems eliminate the need for cleaning validation, reduce the risk of cross-contamination, and offer enhanced flexibility and faster turnaround times between batches.

Is this system suitable for both ultrafiltration and diafiltration?

Yes, systems of this design are typically engineered to perform both ultrafiltration (concentration) and diafiltration (buffer exchange) processes effectively.

What kind of maintenance is typically required for a single-use TFF system?

Maintenance is generally minimal, focusing on calibration of integrated sensors and periodic inspection of the peristaltic pump. The single-use nature reduces the need for extensive cleaning and sterilisation maintenance.

Are the single-use components readily available?

For established manufacturers like Pall, single-use manifold sets and sensors are typically proprietary but widely available through their supply chains.

Can this system be integrated into existing bioprocessing workflows?

Yes, due to their modular design and standard connections, these systems are commonly integrated into various upstream and downstream bioprocessing workflows.

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Used Allegro 1/2" Single Use TFF System - Pharmaceutical Separators

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Available

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Pall - Allegro 1/2" Single Use TFF System

Name: Allegro 1/2" Single Use TFF System
Brand: Pall
SKU: 43011
Price: 30000 GBP
Availability: InStock

Price: £ 30,000

This listing is for a Pall Allegro 1/2" Single Use TFF System.

The unit is in full working condition and is ready for immediate release.

This Unit is fitted with a Ismatec Flowmaster FMT 300 peristaltic pump.

This unit is supplied with Trolley and containers.

The Pall Allegro 1/2" Single Use TFF System is a cutting-edge solution designed specifically for tangential flow filtration (TFF) in bioprocessing applications, combining innovative single-use technology with user-friendly design. Unlike traditional TFF systems, the Allegro system incorporates new concepts that enhance ease of use and efficiency, featuring a carefully considered layout that allows full access to components from one side.

Key Features:

Single-Use Design: Eliminates cross-contamination and cleaning requirements, enhancing system flexibility and ensuring a sterile environment.

Integrated Sensors: Equipped with single-use sensors that track key process parameters, provide notifications for out-of-spec conditions, and enable automated control for optimal processing.

Easy Setup: Comes with five pre-irradiated manifold sets (feed, retentate, permeate, bio container, recovery) that are ready for installation, typically taking just 20 minutes.

Automated Operation: Fully automated for monitoring and controlling critical parameters, ensuring consistent performance throughout ultrafiltration and diafiltration processes.

Technical Specifications:

Capacity: Features a recirculation pump with a capacity of 1,000 L/hour, designed to accommodate m² cassettes running at a crossflow of 5 L/min/m².

Versatile Connections: Easily connects to Allegro 2D and 3D bio containers for WFI, diafiltration buffer, and process fluid in fed batch operations.

Temperature Control: Includes a heat exchange plate under the retentate bio container to manage product temperature, either cooling or heating as needed.

Applications:

Ideal for concentration and diafiltration of proteins, recombinant molecules, potent biological drugs, cytotoxic drugs, and vaccines, the Pall Allegro system stands out as a reliable and efficient choice for modern bioprocessing needs.

Cambridgeshire, United Kingdom

5,791 km away

Model Number

Allegro

Stock Number

43011

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Concentration and diafiltration of proteins, vaccines, and other biologics in pharmaceutical manufacturing.
Clarification of cell cultures and fermentation broths in biotechnology.
Buffer exchange and purification steps in laboratory and pilot-scale bioprocessing.
Virus filtration and removal in the production of biopharmaceuticals.

Typical Specifications

Typical capacity: Recirculation pump capacities for this class of equipment commonly range from hundreds to over 1,000 litres per hour, suitable for various batch sizes.
Power supply: Units of this type typically operate on standard industrial single-phase or three-phase electrical supplies, commonly 230V or 400V, 50Hz in the UK.
Footprint: For systems mounted on a trolley, the footprint is generally compact, allowing for mobility within a laboratory or production environment.
Control system: Modern TFF systems often feature integrated control panels with automated monitoring and control of critical process parameters.
Materials of construction: Process-contacting parts are typically single-use plastic manifolds and membranes, while the system frame and housing are commonly stainless steel.
Membrane area: The effective membrane area for 1/2" systems is typically designed for processing volumes ranging from laboratory to pilot scale.

Frequently Asked Questions

Single-use TFF systems eliminate the need for cleaning validation, reduce the risk of cross-contamination, and offer enhanced flexibility and faster turnaround times between batches.

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.