What is multiple-effect distillation?

Multiple-effect distillation uses a series of evaporators and condensers to generate WFI. The latent heat from the condensing vapour in one effect is used to evaporate water in the next, significantly improving energy efficiency compared to single-effect systems.

How does this system ensure endotoxin removal?

Endotoxin removal is achieved through a combination of pyrogen separation, typically involving a three-stage separation process, and continuous blowdown to remove impurities from the boiling water.

Is this system suitable for pharmaceutical validation?

Yes, systems of this type are designed with features such as sanitary construction, comprehensive instrumentation, and PLC-based controls to facilitate validation processes required for GMP compliance.

What maintenance is typically required for a WFI system?

Routine maintenance commonly includes calibration of instruments, inspection and cleaning of heat exchange surfaces, filter replacement, and periodic checks of pumps and valves to ensure optimal performance and WFI quality.

Can this system be integrated into an existing facility?

WFI generation and storage systems are typically designed with standard utility connections and control interfaces, allowing for integration into existing plant infrastructure, though specific site requirements should be verified.

used Equipment

Available

Verified seller

Steris-Finn Aqua - WFI Generation And Storage System

Name: WFI Generation And Storage System
Brand: Steris-Finn Aqua
SKU: 49353664.1540
Availability: InStock

Price: Contact seller for price

System Overview

A complete, cGMP-compliant Water for Injection (WFI) generation and storage system. Produces high-purity, endotoxin-free water for pharmaceutical and biotech applications via multiple-effect distillation.

This item can be crated and shipped internationally. Please contact us for a quotation

Main Components

Finn-Aqua 200-S3 Distillation Unit – three-effect evaporator/condensers with falling-film design, pyrogen separation, and continuous blowdown.
600 L WFI Storage Tank – 316L stainless steel, atmospheric vent filter, level and temperature sensors.
600 L Jacketed Holding Tank – 316L stainless steel, insulated, steam/hot water jacket for temperature control.
WFI Distribution Pump – sanitary centrifugal pump for loop circulation.
Utility Connections – plant steam (3–8 bar), cooling water, feed water, condensate return, and instrument air.
Instrumentation – pressure, temperature, conductivity, and level transmitters with safety and relief valves.
Control Panel – PLC-based automatic operation, alarm handling, data logging, and local/remote control.

Key Features

Multi-effect distillation for high purity and energy efficiency.
Degassing and three-stage separation for endotoxin removal.
Fully stainless, drainable, and sanitary construction.
Compact, skid-mounted design with integrated utilities.
Designed for validation and GMP compliance (USP/EP WFI quality).

Cambridgeshire, United Kingdom

5,791 km away

Stock Number

49353664.1540

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Production of Water for Injection (WFI) for pharmaceutical formulations and active pharmaceutical ingredient (API) synthesis.
Supply of high-purity water for cleaning-in-place (CIP) and sterilisation-in-place (SIP) systems in biopharmaceutical facilities.
Use in laboratory applications requiring endotoxin-free water, such as cell culture media preparation and analytical testing.
Provision of WFI for sterile manufacturing processes, including injectables and ophthalmic solutions.

Typical Specifications

Typical WFI Production Capacity: For this class of equipment, production capacities commonly range from 100 to 2,000 litres per hour, depending on the specific model and number of effects.
Storage Tank Volume: WFI storage tanks typically range from 500 to 5,000 litres, designed to maintain WFI quality and supply demand.
Materials of Construction: Product contact parts are typically constructed from 316L stainless steel, with electropolished surfaces for optimal hygiene and corrosion resistance.
Utility Requirements: Units of this type commonly require plant steam (typically 3-8 bar), cooling water, feed water, and instrument air for operation.
Footprint: Skid-mounted systems are designed for a compact footprint, with dimensions varying but typically requiring several square metres of floor space.
Power Supply: Control systems and pumps commonly operate on a 400V, 3-phase, 50Hz supply, with specific power draw depending on pump sizes and heating elements.
Compliance: Systems are typically designed to meet cGMP requirements and produce WFI compliant with USP, EP, and JP pharmacopoeia standards.

Frequently Asked Questions

Multiple-effect distillation uses a series of evaporators and condensers to generate WFI. The latent heat from the condensing vapour in one effect is used to evaporate water in the next, significantly improving energy efficiency compared to single-effect systems.

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.