What is the primary function of an Akta Crossflow system?

The primary function is tangential flow filtration (TFF), used for concentrating, diafiltering (buffer exchange), or clarifying biological samples in bioprocessing applications.

Can this system be used for both ultrafiltration and microfiltration?

Yes, Akta Crossflow systems are versatile and can be configured for both ultrafiltration and microfiltration by selecting appropriate filtration cassettes (membranes).

Is this unit suitable for GMP environments?

Akta Crossflow systems are designed with features like CIP capabilities and use biocompatible materials, making them commonly suitable for use in GMP-compliant biopharmaceutical manufacturing environments.

What are the typical benefits of using an automated crossflow system?

Automated systems reduce operator error, improve process reproducibility, offer precise control over filtration parameters, and are often scalable for different production needs.

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Akta Crossflow Filtration System

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Used Akta Crossflow Filtration System - Separators & Extraction Systems

used Equipment

Available

Verified seller

Akta PD - Akta Crossflow Filtration System

Name: Akta Crossflow Filtration System
Brand: Akta PD
SKU: 41683. R2A
Availability: InStock

Price: Contact seller for price

This listing is for the Akta crossflow filtration system.

The unit is in full working condition and is ready for immediate use.

An ÄKTA Crossflow filtration system is a type of tangential flow filtration (TFF) system developed by Cytiva (formerly GE Healthcare).

It's used primarily in bioprocessing and biotechnology applications to concentrate, diafilter, or clarify biological samples such as proteins, viruses, plasmids, and other biomolecule.

Core Functions:

Concentration – Reducing the volume of a sample while retaining the target biomolecule.
Diafiltration (Buffer Exchange) – Removing salts or changing the buffer environment by continuously adding a new buffer while removing permeate.
Clarification – Removing particulates or cells from process fluids.

Key Components:

Pump Modules: Typically peristaltic pumps that manage flow rates precisely.
Filtration Cassettes: Hollow fiber or flat sheet membranes for ultrafiltration or microfiltration.
Pressure Sensors: To monitor and control transmembrane pressure (TMP).
Conductivity/pH/UV Detectors: For in-line monitoring of the filtrate and retentate.

Benefits:

Automation reduces operator error and variability.
Scalable design for seamless transition from lab to production.
Precise control of filtration parameters (flow rate, pressure, volume).
CIP (Clean-In-Place) capabilities for easy maintenance and compliance with GMP.

Common Applications:

Protein concentration and buffer exchange.
Viral vector purification.
Plasmid DNA purification.
Cell harvest and clarification.

Cambridgeshire, United Kingdom

5,773 km away

Model Number

Crossflow

Stock Number

41683. R2A

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Concentration and buffer exchange of proteins and other biomolecules.
Purification of viral vectors and plasmid DNA.
Clarification of cell cultures and fermentation broths.
Small-scale to pilot-scale biopharmaceutical manufacturing.
Research and development in biotechnology laboratories.

Typical throughput: Varies significantly based on membrane area and application, typically handling volumes from millilitres to tens of litres per hour for this class of system.
Power supply: Commonly operates on standard laboratory single-phase power, typically 230V, 50Hz in the UK.
Membrane types: Utilises various hollow fibre or flat sheet membranes for ultrafiltration or microfiltration, with a range of pore sizes and molecular weight cut-offs.
Control system: Features integrated automation for precise control of flow rates, pressures, and volumes, often with software for method development and data logging.
Materials of construction: Wetted parts are typically made from biocompatible materials such as stainless steel and medical-grade plastics suitable for GMP environments.
Maintenance: Designed with Clean-In-Place (CIP) capabilities to facilitate automated cleaning and sanitisation procedures.

The primary function is tangential flow filtration (TFF), used for concentrating, diafiltering (buffer exchange), or clarifying biological samples in bioprocessing applications.

Separators and extraction systems are valued for their reliability in sample preparation workflows across laboratory and pharmaceutical settings. Buyers typically seek equipment with robust construction and minimal downtime history. Key considerations when purchasing used units include chamber integrity, seal condition, and calibration documentation. Industry sentiment favours models offering consistent reproducibility and easy maintenance. Established brands generally command confidence due to parts availability and technical support, though thorough inspection and performance testing remain essential before purchase.

General overview for this equipment type

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.