GE Healthcare UniFlux 120 TFF System

• Biopharmaceutical processing for clarification and concentration.
• Monoclonal antibody purification and buffer exchange.
• Vaccine production and viral particle concentration.
• Protein concentration and diafiltration in pilot to manufacturing scales.

Typical flow rate range

For this class of equipment, units commonly offer a flow rate range of 12 to 120 litres per minute.

Filtration membrane compatibility

Typically supports both cassette and hollow fiber membranes, offering versatility for various applications.

Pump type

Units of this type commonly feature a rotary lobe pump for precise flow control.

Automation

Fully automated operation is standard, often controlled by software such as UNICORN for process management and data logging.

Construction material

Commonly constructed from stainless steel to meet sanitary and GMP compliance requirements.

Regulatory compliance

Designed to meet GMP standards, suitable for pharmaceutical and biotechnology environments.

• What is Tangential Flow Filtration (TFF)?

  TFF is a filtration method where the feed stream flows tangentially across the membrane surface, rather than perpendicularly. This minimises membrane fouling and allows for continuous processing, making it suitable for concentration, diafiltration, and clarification.

• Can this system be used for both pilot and manufacturing scale operations?

• What kind of membranes can be used with this system?

• Is specialised software required to operate this system?

• What are the typical maintenance requirements for a TFF system?

Separators and extraction systems are valued for their reliability in sample preparation workflows across laboratory and pharmaceutical settings. Buyers typically seek equipment with robust construction and minimal downtime history. Key considerations when purchasing used units include chamber integrity, seal condition, and calibration documentation. Industry sentiment favours models offering consistent reproducibility and easy maintenance. Established brands generally command confidence due to parts availability and technical support, though thorough inspection and performance testing remain essential before purchase.

General overview for this equipment type