Amersham Pharma - Amersham Pharma 35L BPG Cromatography Column

Applications & Use Cases

• Downstream purification of proteins and antibodies in biopharmaceutical manufacturing.
• Separation of biologics and other large molecules in pilot and production scale processes.
• Use in GMP-regulated environments requiring high cleanliness and sterility.
• Chromatographic separation steps in vaccine production and plasma fractionation.

Typical Specifications

Typical capacity

BPG columns of this type are typically available in various volumes, with this unit being a 35-litre capacity.

Column material

Commonly constructed from borosilicate glass for the column tube, with wetted parts often made from hygienic polymers (e.g., PEEK, PTFE) and stainless steel.

Operating pressure

For this class of equipment, typical operating pressures can range up to 3-5 bar, depending on column diameter and packing material.

Temperature range

Units are commonly designed to operate within a temperature range suitable for bioprocessing, typically 4°C to 40°C.

Sealing mechanism

Often features a robust, hygienic sealing mechanism, such as inflatable seals, to ensure leak-free operation and easy bed height adjustment.

Connectivity

Typically equipped with industry-standard hygienic connections (e.g., Tri-Clamp) for integration into process lines.

Frequently Asked Questions

• What does BPG stand for?

  BPG stands for BioProcess Glass, indicating that these are glass columns designed for biopharmaceutical process-scale applications.

• What types of chromatography can be performed with this column?

• Is this column suitable for GMP environments?

• What maintenance is typically required for a BPG column?

• Can this column be automated?