GE Healthcare (now Cytiva) - GE Healthcare BPG 300/500 Chromatography Column

Applications & Use Cases

• Large-scale protein purification in biopharmaceutical manufacturing.
• Process chromatography for vaccine production and plasma fractionation.
• Separation and purification of biomolecules in research and development settings.
• Industrial-scale purification of enzymes and other biological products.

Typical Specifications

Typical Column Diameter

For this model series, diameters commonly range from 100 mm up to 600 mm or more, with this unit specifically noted as 300 mm.

Typical Column Height

Column heights for BPG series units typically vary from 300 mm to 1000 mm, with this unit specifically noted as 500 mm.

Materials of Construction

Typically constructed from biocompatible materials such as borosilicate glass and inert polymers (e.g., PEEK, PTFE) for wetted parts.

Operating Pressure

Units of this class commonly operate at pressures up to 5 bar, depending on the specific model and packing material.

Temperature Range

Typically designed for operation within a temperature range suitable for biological applications, often 4°C to 40°C.

Flow Rate

Maximum flow rates are dependent on column dimensions and media, but large BPG columns are designed for high throughput process applications.

Footprint

The footprint will vary based on the column diameter and height, requiring adequate floor space and headroom for operation and maintenance.

Frequently Asked Questions

• What types of chromatography media are compatible with BPG columns?

  BPG columns are designed to be compatible with a wide range of chromatography media, including ion exchange, affinity, size exclusion, and hydrophobic interaction resins, particularly those used in large-scale bioprocessing.

• Is specialist installation required for this type of column?

• What maintenance is typically involved for a used chromatography column?

• Can this column be integrated into an existing chromatography system?

• What are the considerations for packing a large-scale chromatography column?