What is retentate filtration?

Retentate filtration, often referring to Tangential Flow Filtration (TFF), is a process where a fluid is passed tangentially across a membrane, allowing smaller molecules to pass through (permeate) while larger molecules are retained and concentrated (retentate).

Can this unit be scaled up for larger production?

Yes, systems like this often feature identical fluid path lengths, which are designed to enable precise linear scale-up to larger process systems, simplifying process transfer from development to manufacturing.

What maintenance is typically required for this equipment?

Routine maintenance commonly involves cleaning and sanitisation of the fluid path and membrane holders, periodic inspection of seals and connections, and replacement of membranes as needed. Tool-free cassette removal simplifies these tasks.

Is this unit suitable for sterile applications?

Many TFF systems, particularly those with 316L Stainless Steel components, are designed for cleanroom environments and can be sterilised (e.g., by autoclaving or Clean-In-Place/Sterilise-In-Place methods) to meet pharmaceutical requirements.

used Equipment

Available

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PAL (Cytiva) - C145824 Retentate Filtration

Name: C145824 Retentate Filtration
Brand: PAL (Cytiva)
SKU: 37032.SR9B
Price: 195 GBP
Availability: InStock

Price: £ 195

This listing is for a single Pall (Now part of Cytiva) CSUH 040 Feed Retentate

The unit is in full working condition and is ready for immediate use

Designed for optimum performance and product recovery, Centramate™ TFF cassette holders, part of the Pall filtration portfolio, are available in a variety of sizes to meet your application requirements. These holders support efficient concentration, purification, and buffer exchange of biomolecules, making them ideal for small batch production, process development, and Phase I clinical studies.

Identical fluid path lengths ensure precise linear scale-up to larger process systems.

Tool-free cassette removal simplifies workflows—no need to disassemble system plumbing.

Available in:

316L Stainless Steel (Centramate system) for robust, high-performance applications.

Ultra-High Molecular Weight Polyethylene (PE) (Centramate PE system) for a more economical yet durable alternative.

A variety of membrane types and screen options are available for system versatility and application-specific performance.

Cambridgeshire, United Kingdom

5,791 km away

Model Number

C145824 Retentate

Stock Number

37032.SR9B

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Concentration and purification of biomolecules in laboratory and pilot-scale settings.
Buffer exchange for protein solutions and other biopharmaceutical products.
Process development and optimisation for larger-scale filtration systems.
Small batch production in pharmaceutical and biotechnology industries.
Phase I clinical studies requiring sterile and precise separation.

Typical Specifications

Typical capacity: For this class of equipment, processing volumes typically range from several litres up to tens of litres, depending on the installed membrane area.
Power supply: Units of this type commonly require a standard single-phase electrical supply for ancillary pumps and controls, typically 230V, 50Hz in the UK.
Materials of construction: Commonly, wetted parts are constructed from 316L Stainless Steel or Ultra-High Molecular Weight Polyethylene (PE) for chemical compatibility and durability.
Membrane compatibility: This equipment typically supports a variety of TFF membrane types (e.g., ultrafiltration, microfiltration) and molecular weight cut-offs (MWCOs) to suit specific separation needs.
Footprint: For this size of unit, a compact benchtop or small mobile cart footprint is typical, suitable for laboratory or cleanroom environments.
Operating pressure: Operating pressures for retentate filtration systems commonly range from 0.5 to 5 bar, depending on the membrane and application.

Frequently Asked Questions

Retentate filtration, often referring to Tangential Flow Filtration (TFF), is a process where a fluid is passed tangentially across a membrane, allowing smaller molecules to pass through (permeate) while larger molecules are retained and concentrated (retentate).

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.