What is the primary function of an auxiliary pump in a TFF system?

An auxiliary pump, such as the KMPi, is typically used to manage the diafiltration buffer flow, enabling efficient buffer exchange and purification during the TFF process.

Can this system handle different types of filters?

Yes, TFF systems in this category are generally versatile, designed to accommodate both hollow fibre filters and flat sheet cassettes, depending on the application and volume requirements.

Is this unit suitable for GMP environments?

While this specific unit is used, systems of this design are often employed in R&D and process development. For GMP manufacturing, further validation and specific certifications would typically be required.

What kind of maintenance does a TFF system typically require?

Maintenance usually involves regular cleaning and sterilisation of fluid paths, periodic replacement of tubing and seals, and calibration of integrated sensors like scales.

What are the benefits of tangential flow filtration over dead-end filtration?

TFF minimises membrane fouling by continuously sweeping the membrane surface, allowing for higher throughput, longer filter life, and the ability to concentrate samples more effectively compared to dead-end filtration.

used Equipment

Available

Verified seller

Spectrum Labs - KrosFLO TFF System KMPi Auxiliary Pump For Diafiltration

Name: KrosFLO TFF System KMPi Auxiliary Pump For Diafiltration
Brand: Spectrum Labs
SKU: 49123
Availability: InStock

Price: Contact seller for price

This listing is for the Spectrum Labs KrosFlow KR2i TFF System

The unit is in full working condition and is ready for immediate release

The KR2i TFF System is a versatile tangential flow filtration system, suitable for running volumes from 2 mL up to 10 L. It consists of a pump, tablet controller, scale, module stand, and real-time data collection software. The KR2i can mount up to two pump heads, allowing users to add an additional one if desired.

Key Features of KR2i TFF System:

Hollow fiber filter for 2 mL to 10 L / Flat sheet cassettes can process 12 mL to 15 L

Auxiliary pump (): 600 RPM

SAW-KR21 Scale: Capacity up to 20 kg with readability of 0.2 g

Scale platform size: 18 x 18 cm

Tablet control for ease of operation and real-time monitoring

IP33-rated plastic enclosure is easy to clean

Assortment of accessories included (see photos)

The KR2i pump is designed to handle abrasive slurries, corrosive fluids, and highly viscous fluids with minimal wear. The system ensures that the fluid only comes into contact with the tubing and tube material, eliminating valves that could clog and making the inner surfaces easy to clean. With its compact footprint and versatility, the KR2i is an ideal choice for small-volume, R&D-scale microfiltration and ultrafiltration

Cambridgeshire, United Kingdom

5,791 km away

Model Number

KrosFLO TFF System KMPi Auxiliary Pump for Diafiltration

Stock Number

49123

Machinery Masters View

Typical context for this category of equipment. Always confirm specifics with the seller.

Applications & Use Cases

Concentration and diafiltration of proteins, viruses, and nanoparticles in biopharmaceutical research.
Clarification of cell cultures and fermentation broths in laboratory settings.
Small-scale purification of vaccines and therapeutic proteins.
Buffer exchange and desalting of biological samples.
R&D-scale microfiltration and ultrafiltration processes for process development.

Typical Specifications

Typical processing volume: For this class of equipment, processing volumes commonly range from a few millilitres up to 10-15 litres.
Pump type: Units of this type typically feature peristaltic pumps, suitable for handling various fluid types with minimal shear.
Filtration mode: Designed for tangential flow filtration (TFF), utilising either hollow fibre filters or flat sheet cassettes.
Power supply: Commonly operates on standard laboratory power, typically 230V, 50Hz for the UK market.
Control interface: Modern systems often include a tablet or touchscreen interface for ease of operation and real-time monitoring.
Footprint: Typically designed with a compact footprint, suitable for benchtop use in laboratory environments.
Scale integration: Many systems integrate a scale for gravimetric control and accurate volume monitoring during processing.

Frequently Asked Questions

An auxiliary pump, such as the KMPi, is typically used to manage the diafiltration buffer flow, enabling efficient buffer exchange and purification during the TFF process.

Machinery Masters Intelligence. General guidance for this category of equipment only, not a substitute for the seller's exact specifications. Always confirm details with the seller.