Chromatography Systems (HPLC, UHPLC, GC, LCMS, GPC-SEC)
A chromatography system separates a complex sample into its individual components so each can be identified and measured, and it remains the backbone of analytical work in pharma, environmental and food labs. This category covers chromatography systems spanning HPLC, UHPLC, GC, LCMS and GPC-SEC, listed as complete configurations or individual modules. Buyers can compare detector options, check pump and autosampler condition, and speak to sellers about run hours and included software. Financing on qualifying listings helps labs acquire a full separation platform without a single heavy outlay.
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Chromatography System Types
Each platform is suited to a different class of analyte and sample matrix, from small molecules to high polymers. The configurations below cover the main separation technologies.
HPLC and UHPLC systems
Liquid chromatography stacks that separate non-volatile compounds under pressure, with UHPLC running finer particles at higher pressures for faster, sharper separations. They handle the bulk of pharmaceutical and QC analysis.
Gas chromatography (GC) systems
Instruments that separate volatile and semi-volatile compounds in the gas phase using capillary columns and temperature programming. They are standard for solvents, residues and volatile impurities.
LCMS platforms
Liquid chromatography coupled to a mass spectrometer for both separation and confident mass-based identification. These systems suit trace analysis and structural confirmation where a detector alone is not enough.
GPC-SEC systems
Gel permeation and size exclusion systems that separate polymers and macromolecules by hydrodynamic size to determine molecular weight distribution. They are essential in polymer and biopharmaceutical characterisation.
Brands on Machinery Masters
Sellers list chromatography systems from established instrument makers whose modules and software are widely supported. Every name below comes from the Chromatography Systems (HPLC, UHPLC, GC, LCMS, GPC-SEC) listings currently available on Machinery Masters, so the strip is rarely the same twice.
Latest Chromatography Systems (HPLC, UHPLC, GC, LCMS, GPC-SEC) Listings
Why Choose Machinery Masters
Verified Sellers Only
Every seller is verified before a single listing goes live. Machinery Masters also reviews listings for accuracy, so buyers can commit to high value machinery with confidence.
Global Reach
Listings come from sellers across Europe, North America, and beyond. That reach widens the options past any regional dealer network, and it is often the only way to find discontinued models in good condition.
Flexible Financing Options
Qualifying listings carry financing through partner providers. Terms are shown directly on eligible product pages, spreading the cost instead of draining working capital in one hit.
Direct Seller Contact
No broker sits between the buyer and the seller. Ask about service history, arrange inspections, and negotiate directly with the person who actually knows the machine.
Applications and Uses
Chromatography systems do measurement work that few other techniques can match for specificity. The settings below show where they are indispensable.
Pharmaceutical assay and impurity testing
Labs quantify active ingredients and profile related substances to prove a product meets specification. HPLC and UHPLC carry most of this regulated workload.
Environmental trace analysis
Contract labs detect pesticides, hydrocarbons and contaminants at low concentrations in water and soil. LCMS and GC provide the sensitivity and confirmation these limits demand.
Polymer and materials characterisation
Researchers measure molecular weight distribution and polydispersity to link structure to material performance. GPC-SEC is the standard technique for this work.
Food safety and authenticity testing
Analysts screen for residues, additives and adulterants to protect consumers and confirm label claims. Chromatography separates these compounds from complex food matrices.
Benefits from Machinery Masters
Sitting under Analytical Instruments & Detection Systems, this category puts complete chromatography systems within reach and connects you with the sellers who know each stack.
Every separation platform under one heading
HPLC, UHPLC, GC, LCMS and GPC-SEC chromatography systems appear together, so you match the technique to your analytes before buying. That comparison is harder when a dealer handles only one platform.
Reach instruments that would be costly bought new
A serviceable used LCMS or UHPLC stack costs far less than the new equivalent while running the same core methods. That opens capabilities a smaller lab could not otherwise justify.
Pin down run hours and modules with the seller
Speaking to the seller settles pump condition, detector type and whether software licences transfer. On complex chromatography systems, that direct answer beats any generic description.
Frequently Asked Questions About Chromatography Systems (HPLC, UHPLC, GC, LCMS, GPC-SEC)
Pump condition, detector type and, on LCMS, source and vacuum health carry the most weight. Ask for run hours or injection counts and any recent service records. Confirm which detectors and columns come with the system and whether the control software licence transfers. These points tell you far more than cosmetic condition about how the instrument will perform.
Detector choice follows your analytes, from UV and diode array for chromophores to fluorescence, refractive index or mass spectrometry for specific needs. Confirm the listed detector suits your method sensitivity requirements. Some systems support more than one detector in series. Matching detector to application is central to getting usable results.
Requirements range from a stable bench and mains power for a basic HPLC to carrier gas, nitrogen and vacuum for GC and LCMS. Confirm gas supply, ventilation and any chiller or nitrogen generator dependencies with the seller. Larger systems also need stable ambient temperature. Planning these utilities before delivery avoids commissioning delays.
Many established platforms remain well supported with columns, lamps, seals and detector parts. Check part availability for the specific model before you buy, particularly for older mass spectrometers. Ask the seller whether wear parts were recently replaced. Confirmed support means an older system can serve reliably for years.
Qualifying listings can be financed, which spreads the cost of an expensive stack over an agreed term. This lets a lab build a complete workflow without one large capital outlay. You finalise the purchase directly with the seller once terms are agreed. Check the individual listing to confirm whether finance is offered.