3M Zeta Plus 16EZA Encapsulated System Holder

This listing is for a 3M Zeta Plus 16EZA Encapsulated System Holder

The unit is in excellent working condition and is ready for immediate release.

The 3M Encapsulated System Holder is engineered to support Zeta Plus depth filtration and related downstream purification processes with optimal ergonomics, hygiene, and operational efficiency.

It is specifically designed for biopharmaceutical and biotechnology applications where sterile, high-throughput filtration is required.

This system holder accommodates encapsulated filter capsules—eliminating the need for a stainless-steel housing—and offers a pivoting, ergonomic frame that enhances operator safety and eases filter change-outs.

Key Features

Pivoting Holder Design – The housing pivots between horizontal (waist-height) for loading/unloading and vertical for filtration mode, reducing operator strain and minimizing fluid spills during replacement.

Vertical Flow Path Retained – Preserves the proven vertical flow design ideal for depth filtration with 3M Zeta Plus filters and compatibility with 3M polisher or chromatographic clarifiers.

Torque-Limiter Sealing – Built-in torque limiter ensures the capsule shell is properly sealed before operation, protecting against leaks or misassembly.

Encapsulated Shell Architecture – Eliminates the need for an external stainless-steel cartridge housing, thereby reducing facility clean‑in‑place (CIP) or validation overhead.

Shell Options – Offers translucent polycarbonate shells for visual liquid level monitoring or polyphenylene oxide shells capable of sterilization and sanitization.

Multiple Flow Configurations Supported – Enables Bottom-In / Bottom-Out and Top-In / Bottom-Out modes to optimize media usage and filter performance.

Scalable Modules – Available in pilot and full-production configurations, facilitating scale‑up from lab to manufacturing scale within a unified system design.

Technical Specifications

Parameter Description

Model / Part No. Housing 16EZA1

Flow Path Vertical flow design, compatible with multiple flow directions

Shell Materials Polycarbonate or polyphenylene oxide options (sterilizable)

Holder Orientation Pivoting between horizontal (load/unload) & vertical (operational)

Sealing Mechanism Torque‑limiter style sealing indicator

Operational Scale Supports systems from small pilot scale up to production scale (0.5 L to >2,500 L)

Filtration Compatibility 3M Zeta Plus depth filters, 3M Polisher ST, 3M Emphaze AEX Hybrid Purifier, 3M Harvest RC, etc.

Footprint Compact vertical footprint; reduced spatial demand in filtration suites

Applications

Clarification of mammalian cell cultures prior to downstream purification

Protection of downstream membranes and chromatography resins via depth filtration

Clarification of bacterial, yeast, or insect cell lysates

Removal of host cell proteins (HCP), DNA, endotoxins, and particulates

Pre‑polishing or polishing after capture chromatography

Viral clearance modes in downstream workflows

Benefits & Value Proposition

Enhanced Ergonomics & Safety – The pivoting design reduces the need to lift used capsules overhead, lowering risk of spills and operator fatigue.

Lower Validation Burden – Because the system is fully encapsulated, no external housing cleaning or validation is needed in the customer’s site.

Operational Versatility – Flexibility in shell types, flow configurations, and scale continuity from pilot to production.

Visual Process Monitoring – Translucent shells facilitate direct observation of liquid levels during filtration.

Scalable Single‑Use Filtration Platform – Ideal for facilities implementing single-use and modular filtration architectures.