Waters ACQUITY UPLC System

• Pharmaceutical research and quality control for drug discovery and impurity profiling.
• Biotechnology for protein and peptide analysis, and biomarker identification.
• Environmental testing for contaminant analysis in water and soil samples.
• Food and beverage analysis for quality control, authenticity, and additive detection.
• Clinical diagnostics for metabolite profiling and therapeutic drug monitoring.

Typical flow rate range

Commonly 0.01 to 2.0 mL/min, with precise control for various applications.

Maximum operating pressure

Typically up to 15,000 psi (1034 bar) for this class of equipment, enabling high-resolution separations.

Detector options

Units of this type commonly support UV/Vis, PDA, fluorescence, and mass spectrometry detectors.

Column temperature range

Typically ambient +5°C to 90°C, for optimal separation conditions.

Power supply

Units commonly require a standard laboratory power supply, typically 230V, 50Hz for UK operation.

Footprint

For this class of equipment, a typical UPLC system requires significant bench space, often around 60-80 cm width per module.

• What is the primary advantage of UPLC over traditional HPLC?

  UPLC systems, like the ACQUITY, offer significantly faster separations, higher resolution, and increased sensitivity compared to traditional HPLC, due to their ability to use smaller particle columns at higher pressures.

• Does this unit include the necessary software and licenses?

• What kind of maintenance does a UPLC system typically require?

• Is this UPLC system suitable for GxP regulated environments?

• Can this system be integrated with other laboratory equipment?

Chromatography systems command strong respect within analytical and pharmaceutical sectors. Buyers typically prioritise equipment with verified maintenance records and clear calibration history, as these directly affect analytical accuracy. Used units from established manufacturers remain highly valued for their reliability. Key strengths include reproducible results, robust construction, and established spare parts availability. Industry sentiment reflects confidence in these systems when sourced from reputable suppliers with transparent service documentation.

General overview for this equipment type